Aftin-4
- Product Name
- Aftin-4
- CAS No.
- 866893-90-5
- Chemical Name
- Aftin-4
- Synonyms
- Aftin-4;Aftin-4 >=98% (HPLC);AFTIN-4;AFTIN 4;AFTIN4;N6-methyl-(R)-roscovitine;β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor;(R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol;1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
- CBNumber
- CB73381022
- Molecular Formula
- C20H28N6O
- Formula Weight
- 368.48
- MOL File
- 866893-90-5.mol
Aftin-4 Property
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1578
- Product name
- Aftin-4
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $214
- Updated
- 2023/06/20
- Product number
- SML1578
- Product name
- Aftin-4
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $639
- Updated
- 2023/06/20
- Product number
- 27341
- Product name
- Aftin-4
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 27341
- Product name
- Aftin-4
- Packaging
- 25mg
- Price
- $593
- Updated
- 2024/03/01
- Product number
- 27341
- Product name
- Aftin-4
- Packaging
- 5mg
- Price
- $202
- Updated
- 2024/03/01
Aftin-4 Chemical Properties,Usage,Production
Description
Aftin-4 is an inducer of amyloid-β (1-42) (Aβ42). It selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells when used at concentrations ranging from 1 to 100 mM. In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice. It also induces spatial working and spatial reference memory deficits in mice, effects that are reversed by co-administration of the γ-secretase inhibitor BMS-299,897.
Uses
Aftin 4, is an Amyloid-β42 (Aβ42) inducer, that increases Aβ1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD).
Biochem/physiol Actions
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.
storage
+4°C
Aftin-4 Preparation Products And Raw materials
Raw materials
Preparation Products
Aftin-4 Suppliers
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58